別名
interleukin 3, IL-3, MCGF, MULTI-CSF
背景
白細(xì)胞介素 3(Interleukin-3,IL-3)又稱多集落刺激因子(Multicolony stimulationfactor,Multi-CSF)。此外,IL-3 還曾被命名為暴式集落促進(jìn)因子、WHE ?-3 因子、肥大細(xì)胞因子、組胺刺激的細(xì)胞生長因子、P 細(xì)胞刺激因子、多能集落刺激因子等。
IL-3 主要由活化的 T 細(xì)胞和 NK 細(xì)胞產(chǎn)生,此外,IL-1 激活的人內(nèi)皮細(xì)胞、IgE 激活的小鼠肥大細(xì)胞和胎盤細(xì)胞等也產(chǎn)生 IL-3。其主要作用為促進(jìn)骨髓中多能造血干細(xì)胞的定向分化與增殖,產(chǎn)生各種類型的血細(xì)胞。此外IL-3還可調(diào)節(jié)多種成熟細(xì)胞的生長、分化及相關(guān)的基因表達(dá),如c-myc、IL-2Rα基因等。
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